/* Modern CSS Reset and Variables */
:root {
    /* Modern Color Palette - Light Mode */
    --primary-color: #2563eb;
    --primary-hover: #1d4ed8;
    --primary-light: #dbeafe;
    --secondary-color: #64748b;
    --accent-color: #06b6d4;
    --success-color: #059669;
    --warning-color: #d97706;
    --error-color: #dc2626;
    --danger-color: #b91c1c;
    
    /* Neutral Colors - Light Mode */
    --gray-50: #f8fafc;
    --gray-100: #f1f5f9;
    --gray-200: #e2e8f0;
    --gray-300: #cbd5e1;
    --gray-400: #94a3b8;
    --gray-500: #64748b;
    --gray-600: #475569;
    --gray-700: #334155;
    --gray-800: #1e293b;
    --gray-900: #0f172a;
    
    /* Background Colors - Light Mode */
    --bg-primary: #ffffff;
    --bg-secondary: #f8fafc;
    --bg-tertiary: #f1f5f9;
    --bg-overlay: rgba(15, 23, 42, 0.6);
    
    /* Text Colors - Light Mode */
    --text-primary: #0f172a;
    --text-secondary: #475569;
    --text-tertiary: #64748b;
    --text-inverse: #ffffff;
    
    /* Border Colors - Light Mode */
    --border-primary: #e2e8f0;
    --border-secondary: #cbd5e1;
    --border-focus: #2563eb;
    
    /* Theme Mode */
    --theme-transition: all 0.3s ease;
}

/* Dark Mode Variables */
[data-theme="dark"] {
    /* Modern Color Palette - Dark Mode */
    --primary-color: #3b82f6;
    --primary-hover: #2563eb;
    --primary-light: #1e40af;
    --secondary-color: #94a3b8;
    --accent-color: #06b6d4;
    --success-color: #10b981;
    --warning-color: #f59e0b;
    --error-color: #ef4444;
    --danger-color: #dc2626;
    
    /* Neutral Colors - Dark Mode */
    --gray-50: #1a202c;
    --gray-100: #2d3748;
    --gray-200: #4a5568;
    --gray-300: #718096;
    --gray-400: #a0aec0;
    --gray-500: #cbd5e0;
    --gray-600: #e2e8f0;
    --gray-700: #edf2f7;
    --gray-800: #f7fafc;
    --gray-900: #ffffff;
    
    /* Background Colors - Dark Mode */
    --bg-primary: #1a202c;
    --bg-secondary: #2d3748;
    --bg-tertiary: #4a5568;
    --bg-overlay: rgba(0, 0, 0, 0.7);
    
    /* Text Colors - Dark Mode */
    --text-primary: #f7fafc;
    --text-secondary: #e2e8f0;
    --text-tertiary: #cbd5e0;
    --text-inverse: #1a202c;
    
    /* Border Colors - Dark Mode */
    --border-primary: #4a5568;
    --border-secondary: #718096;
    --border-focus: #3b82f6;
}

/* Shared Variables */
:root {
    /* Spacing Scale */
    --space-xs: 0.25rem;
    --space-sm: 0.5rem;
    --space-md: 1rem;
    --space-lg: 1.5rem;
    --space-xl: 2rem;
    --space-2xl: 3rem;
    --space-3xl: 4rem;
    
    /* Border Radius */
    --radius-sm: 0.375rem;
    --radius-md: 0.5rem;
    --radius-lg: 0.75rem;
    --radius-xl: 1rem;
    --radius-full: 9999px;
    
    /* Shadows */
    --shadow-xs: 0 1px 2px 0 rgba(0, 0, 0, 0.05);
    --shadow-sm: 0 1px 3px 0 rgba(0, 0, 0, 0.1), 0 1px 2px 0 rgba(0, 0, 0, 0.06);
    --shadow-md: 0 4px 6px -1px rgba(0, 0, 0, 0.1), 0 2px 4px -1px rgba(0, 0, 0, 0.06);
    --shadow-lg: 0 10px 15px -3px rgba(0, 0, 0, 0.1), 0 4px 6px -2px rgba(0, 0, 0, 0.05);
    --shadow-xl: 0 20px 25px -5px rgba(0, 0, 0, 0.1), 0 10px 10px -5px rgba(0, 0, 0, 0.04);
    
    /* Typography */
    --font-primary: -apple-system, BlinkMacSystemFont, 'Segoe UI', Roboto, 'Helvetica Neue', Arial, sans-serif;
    --font-mono: 'SF Mono', Monaco, Inconsolata, 'Roboto Mono', Consolas, 'Courier New', monospace;
    
    /* Transitions */
    --transition-fast: 150ms ease-in-out;
    --transition-normal: 250ms ease-in-out;
    --transition-slow: 350ms ease-in-out;
    
    /* Breakpoints */
    --breakpoint-sm: 640px;
    --breakpoint-md: 768px;
    --breakpoint-lg: 1024px;
    --breakpoint-xl: 1280px;
}

/* Dark Mode Theme Toggle */
.theme-toggle {
    background: none;
    border: 1px solid var(--border-primary);
    border-radius: var(--radius-md);
    padding: var(--space-sm) var(--space-md);
    color: var(--text-primary);
    cursor: pointer;
    font-size: 0.875rem;
    transition: all var(--transition-fast);
    display: flex;
    align-items: center;
    gap: var(--space-xs);
    position: relative;
    z-index: 20;
    min-height: 40px;
}

.theme-toggle:hover {
    background-color: var(--bg-secondary);
    border-color: var(--border-secondary);
}

.theme-toggle:focus {
    outline: none;
    border-color: var(--border-focus);
    box-shadow: 0 0 0 2px rgba(59, 130, 246, 0.1);
}

.theme-toggle .theme-icon {
    font-size: 1rem;
}

/* Dark Theme Override */
[data-theme="dark"] {
    /* Background Colors - Dark Mode */
    --bg-primary: #0f172a;
    --bg-secondary: #1e293b;
    --bg-tertiary: #334155;
    --bg-accent: #1e40af;
    
    /* Text Colors - Dark Mode */
    --text-primary: #f8fafc;
    --text-secondary: #e2e8f0;
    --text-tertiary: #cbd5e0;
    --text-inverse: #0f172a;
    
    /* Border Colors - Dark Mode */
    --border-primary: #475569;
    --border-secondary: #64748b;
    --border-focus: #3b82f6;
    
    /* Update component-specific colors for dark mode */
    --primary-color: #2563eb;
    --secondary-color: #64748b;
    --accent-color: #7c3aed;
    --success-color: #059669;
    --warning-color: #d97706;
    --error-color: #dc2626;
    
    /* Gray scale for dark mode */
    --gray-50: #0f172a;
    --gray-100: #1e293b;
    --gray-200: #334155;
    --gray-300: #475569;
    --gray-400: #64748b;
    --gray-500: #94a3b8;
    --gray-600: #cbd5e0;
    --gray-700: #e2e8f0;
    --gray-800: #f1f5f9;
    --gray-900: #f8fafc;
}

/* Force dark mode styles on all major elements */
[data-theme="dark"] body {
    background-color: #0f172a !important;
    color: #f8fafc !important;
}

[data-theme="dark"] .header {
    background: linear-gradient(135deg, #1e293b 0%, #334155 100%) !important;
    color: #f8fafc !important;
}

[data-theme="dark"] .sidebar {
    background: linear-gradient(to bottom, #334155 0%, #1e293b 100%) !important;
    border-right: 1px solid #475569 !important;
}

[data-theme="dark"] .main-content {
    background-color: #0f172a !important;
    color: #f8fafc !important;
}

[data-theme="dark"] .content-wrapper {
    background: #0f172a !important;
}

[data-theme="dark"] .instruction-content {
    background: linear-gradient(135deg, #1e293b 0%, #334155 100%) !important;
    border: 1px solid #475569 !important;
    color: #f8fafc !important;
}

[data-theme="dark"] .form-control {
    background-color: #1e293b !important;
    border: 1px solid #475569 !important;
    color: #f8fafc !important;
}

[data-theme="dark"] .form-control:focus {
    background-color: #334155 !important;
    border-color: #3b82f6 !important;
    box-shadow: 0 0 0 2px rgba(59, 130, 246, 0.3) !important;
}

[data-theme="dark"] .form-control::placeholder {
    color: #94a3b8 !important;
}

[data-theme="dark"] .btn-primary {
    background-color: #2563eb !important;
    border-color: #2563eb !important;
    color: #f8fafc !important;
}

[data-theme="dark"] .btn-primary:hover {
    background-color: #1d4ed8 !important;
    border-color: #1d4ed8 !important;
}

[data-theme="dark"] .theme-toggle {
    background-color: #1e293b !important;
    border-color: #475569 !important;
    color: #f1f5f9 !important;
}

[data-theme="dark"] .theme-toggle:hover {
    background-color: #334155 !important;
    border-color: #64748b !important;
    color: #ffffff !important;
}

[data-theme="dark"] .input-section {
    background-color: #334155 !important;
    border: 1px solid #475569 !important;
    border-radius: 8px !important;
    padding: 1.5rem !important;
    box-shadow: 0 2px 4px rgba(0, 0, 0, 0.3) !important;
}

[data-theme="dark"] .input-header {
    color: #f8fafc !important;
}

[data-theme="dark"] select {
    background-color: #1e293b !important;
    border: 1px solid #475569 !important;
    color: #f8fafc !important;
}

[data-theme="dark"] select option {
    background-color: #1e293b !important;
    color: #f8fafc !important;
}

[data-theme="dark"] .medication-dropdown {
    background-color: #1e293b !important;
    border: 1px solid #475569 !important;
    color: #f8fafc !important;
}

[data-theme="dark"] .medication-item {
    color: #f8fafc !important;
}

[data-theme="dark"] .medication-item:hover {
    background-color: #334155 !important;
}

[data-theme="dark"] .selected-medications {
    background-color: #1e293b !important;
    border: 1px solid #475569 !important;
}

[data-theme="dark"] .selected-med {
    background-color: #334155 !important;
    color: #f8fafc !important;
    border: 1px solid #475569 !important;
}

[data-theme="dark"] h1, 
[data-theme="dark"] h2, 
[data-theme="dark"] h3, 
[data-theme="dark"] h4, 
[data-theme="dark"] h5, 
[data-theme="dark"] h6 {
    color: #f1f5f9 !important;
    text-shadow: 0 1px 2px rgba(0, 0, 0, 0.2);
}

[data-theme="dark"] p {
    color: #e2e8f0 !important;
}

[data-theme="dark"] label {
    color: #f1f5f9 !important;
    font-weight: 600 !important;
}

[data-theme="dark"] .help-text {
    color: #cbd5e1 !important;
}

/* Additional dark mode contrast improvements */
[data-theme="dark"] .form-group label {
    color: #f1f5f9 !important;
    text-shadow: 0 1px 2px rgba(0, 0, 0, 0.3);
}

[data-theme="dark"] .input-header {
    color: #f1f5f9 !important;
    font-weight: 700 !important;
}

[data-theme="dark"] .sidebar-content h2 {
    color: #f1f5f9 !important;
    text-shadow: 0 1px 2px rgba(0, 0, 0, 0.3);
}

[data-theme="dark"] .footer {
    background: linear-gradient(135deg, #1e293b 0%, #334155 100%) !important;
    color: #f1f5f9 !important;
}

[data-theme="dark"] .footer p {
    color: #e2e8f0 !important;
}

[data-theme="dark"] .disclaimer-summary {
    color: #f1f5f9 !important;
}

[data-theme="dark"] .disclaimer-content {
    color: #e2e8f0 !important;
}

[data-theme="dark"] .warning-box {
    background: linear-gradient(135deg, rgba(251, 191, 36, 0.15) 0%, rgba(245, 158, 11, 0.1) 100%) !important;
    border: 1px solid rgba(251, 191, 36, 0.4) !important;
    color: #fcd34d !important;
}

[data-theme="dark"] .info-box {
    color: #e2e8f0 !important;
    background: rgba(59, 130, 246, 0.15) !important;
    border: 1px solid rgba(59, 130, 246, 0.3) !important;
}

/* Improve contrast for various text elements */
[data-theme="dark"] .medication-option {
    color: #f1f5f9 !important;
    background-color: #334155 !important;
}

[data-theme="dark"] .medication-option:hover {
    background-color: #475569 !important;
    color: #ffffff !important;
}

[data-theme="dark"] .tab-button {
    color: #e2e8f0 !important;
    border-color: #475569 !important;
}

[data-theme="dark"] .tab-button.active {
    color: #ffffff !important;
    background: linear-gradient(135deg, #2563eb 0%, #3b82f6 100%) !important;
}

[data-theme="dark"] .metric-label {
    color: #cbd5e1 !important;
}

[data-theme="dark"] .profile-header {
    color: #f1f5f9 !important;
}

[data-theme="dark"] .recommendation-box p {
    color: #60a5fa !important;
}

[data-theme="dark"] .no-adjustment-box p {
    color: #34d399 !important;
}

[data-theme="dark"] .error-message {
    color: #fca5a5 !important;
    background: linear-gradient(135deg, rgba(239, 68, 68, 0.15) 0%, rgba(220, 38, 38, 0.1) 100%) !important;
}

/* Enhanced readability for both light and dark modes */
/* Ensure good contrast in light mode (default) */
.form-group label {
    color: var(--text-primary);
    font-weight: 600;
    text-shadow: none;
}

.input-header {
    color: var(--text-primary);
    font-weight: 700;
}

/* Enhanced CSS Reset */
*,
*::before,
*::after {
    margin: 0;
    padding: 0;
    box-sizing: border-box;
}

html {
    line-height: 1.5;
    -webkit-text-size-adjust: 100%;
    text-size-adjust: 100%;
    -moz-tab-size: 4;
    tab-size: 4;
    scroll-behavior: smooth;
}

body {
    font-family: var(--font-primary);
    line-height: 1.6;
    color: var(--text-primary);
    background-color: var(--bg-primary);
    font-size: 16px;
    overflow-x: hidden;
    transition: background-color var(--transition-normal), color var(--transition-normal);
}

/* Enhanced Typography */
h1, h2, h3, h4, h5, h6 {
    font-weight: 600;
    line-height: 1.25;
    letter-spacing: -0.025em;
}

h1 { font-size: 2.5rem; }
h2 { font-size: 2rem; }
h3 { font-size: 1.5rem; }
h4 { font-size: 1.25rem; }
h5 { font-size: 1.125rem; }
h6 { font-size: 1rem; }

/* Focus Management */
:focus-visible {
    outline: 2px solid var(--primary-color);
    outline-offset: 2px;
}

/* Loading Screen with Animation */
.loading-screen {
    position: fixed;
    top: 0;
    left: 0;
    width: 100%;
    height: 100%;
    background: linear-gradient(135deg, var(--primary-color) 0%, var(--accent-color) 100%);
    display: flex;
    justify-content: center;
    align-items: center;
    z-index: 9999;
    -webkit-backdrop-filter: blur(10px);
    backdrop-filter: blur(10px);
}

.loading-content {
    text-align: center;
    color: var(--text-inverse);
    animation: fadeInUp 0.6s ease-out;
}

.spinner {
    width: 60px;
    height: 60px;
    border: 4px solid rgba(255, 255, 255, 0.2);
    border-top: 4px solid var(--text-inverse);
    border-radius: var(--radius-full);
    animation: spin 1s linear infinite, pulse 2s ease-in-out infinite;
    margin: 0 auto var(--space-lg);
}

.loading-content p {
    font-size: 1.125rem;
    font-weight: 500;
    opacity: 0.9;
}

/* Animations */
@keyframes spin {
    0% { transform: rotate(0deg); }
    100% { transform: rotate(360deg); }
}

@keyframes pulse {
    0%, 100% { transform: scale(1); }
    50% { transform: scale(1.05); }
}

@keyframes fadeInUp {
    from {
        opacity: 0;
        transform: translateY(30px);
    }
    to {
        opacity: 1;
        transform: translateY(0);
    }
}

@keyframes slideInRight {
    from {
        opacity: 0;
        transform: translateX(30px);
    }
    to {
        opacity: 1;
        transform: translateX(0);
    }
}

@keyframes fadeIn {
    from { opacity: 0; }
    to { opacity: 1; }
}

/* Modern Main Layout */
.main-container {
    min-height: 100vh;
    display: flex;
    flex-direction: column;
    background: linear-gradient(135deg, var(--bg-secondary) 0%, var(--bg-tertiary) 100%);
}

/* Modern Header with Gradient */
.header {
    background: linear-gradient(135deg, var(--primary-color) 0%, var(--accent-color) 100%);
    color: var(--text-inverse);
    padding: var(--space-xl) var(--space-lg);
    border-bottom: none;
    position: relative;
    overflow: hidden;
}

.header::before {
    content: '';
    position: absolute;
    top: 0;
    left: 0;
    right: 0;
    bottom: 0;
    background: url('data:image/svg+xml,<svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 100 100"><defs><pattern id="grain" width="100" height="100" patternUnits="userSpaceOnUse"><circle cx="50" cy="50" r="1" fill="white" opacity="0.1"/></pattern></defs><rect width="100" height="100" fill="url(%23grain)"/></svg>');
    pointer-events: none;
}

.header h1 {
    font-size: clamp(2rem, 4vw, 3rem);
    font-weight: 700;
    margin-bottom: var(--space-sm);
    letter-spacing: -0.05em;
    position: relative;
    z-index: 1;
}

.header p {
    font-size: 1.125rem;
    opacity: 0.95;
    max-width: 600px;
    position: relative;
    z-index: 1;
}

.header-content {
    display: flex;
    justify-content: space-between;
    align-items: flex-start;
    gap: var(--space-lg);
    position: relative;
    z-index: 1;
}

.header-text {
    flex: 1;
}

.header-controls {
    flex-shrink: 0;
    display: flex;
    align-items: center;
    gap: var(--space-md);
    position: relative;
    z-index: 10;
}

/* Enhanced Content Wrapper */
.content-wrapper {
    display: grid;
    grid-template-columns: 380px 1fr;
    flex: 1;
    min-height: calc(100vh - 200px);
    gap: 0;
    background: var(--bg-primary);
    box-shadow: var(--shadow-lg);
    border-radius: var(--radius-xl) var(--radius-xl) 0 0;
    margin-top: -var(--space-lg);
    position: relative;
    z-index: 2;
    overflow: hidden;
}

/* Modern Sidebar */
.sidebar {
    background: linear-gradient(to bottom, var(--bg-primary) 0%, var(--bg-secondary) 100%);
    border-right: 1px solid var(--gray-200);
    overflow-y: auto;
    flex-shrink: 0;
    position: relative;
}

.sidebar::before {
    content: '';
    position: absolute;
    top: 0;
    right: 0;
    width: 1px;
    height: 100%;
    background: linear-gradient(to bottom, transparent, var(--gray-300), transparent);
}

.sidebar-content {
    padding: var(--space-xl);
    position: relative;
    z-index: 1;
}

.sidebar h2 {
    color: var(--text-primary);
    margin-bottom: var(--space-xl);
    font-size: 1.75rem;
    font-weight: 700;
    display: flex;
    align-items: center;
    gap: var(--space-sm);
}

.sidebar h2::before {
    content: '👥';
    font-size: 1.5rem;
}

/* Enhanced Input Sections */
.input-section {
    margin-bottom: var(--space-2xl);
    animation: fadeInUp 0.6s ease-out;
    animation-fill-mode: both;
}

.input-section:nth-child(2) { animation-delay: 0.1s; }
.input-section:nth-child(3) { animation-delay: 0.2s; }
.input-section:nth-child(4) { animation-delay: 0.3s; }

.input-header {
    font-size: 1.125rem;
    font-weight: 700;
    margin-bottom: var(--space-lg);
    color: var(--text-primary);
    position: relative;
    padding-bottom: var(--space-sm);
}

.input-header::after {
    content: '';
    position: absolute;
    bottom: 0;
    left: 0;
    width: 40px;
    height: 3px;
    background: linear-gradient(to right, var(--primary-color), var(--accent-color));
    border-radius: var(--radius-full);
}

/* Modern Form Controls */
.form-group {
    margin-bottom: var(--space-lg);
    position: relative;
}

.form-group label {
    display: block;
    margin-bottom: var(--space-sm);
    font-weight: 600;
    color: var(--text-primary);
    font-size: 0.875rem;
    text-transform: uppercase;
    letter-spacing: 0.05em;
    transition: color var(--transition-fast);
}

.form-control {
    width: 100%;
    padding: var(--space-md);
    border: 2px solid var(--gray-200);
    border-radius: var(--radius-lg);
    font-size: 1rem;
    background: var(--bg-primary);
    color: var(--text-primary);
    transition: all var(--transition-normal);
    position: relative;
    font-family: var(--font-primary);
}

.form-control:focus {
    outline: none;
    border-color: var(--primary-color);
    box-shadow: 0 0 0 3px rgba(37, 99, 235, 0.1);
    transform: translateY(-1px);
}

.form-control:hover:not(:focus) {
    border-color: var(--gray-300);
}

.form-control::placeholder {
    color: var(--gray-400);
    transition: color var(--transition-fast);
}

.form-control:focus::placeholder {
    color: var(--gray-300);
}

/* Enhanced Help Text */
.help-text {
    display: block;
    margin-top: var(--space-sm);
    font-size: 0.8125rem;
    color: var(--text-tertiary);
    line-height: 1.4;
}

/* Modern Medication Selection */
.medication-select-container {
    position: relative;
}

.medication-dropdown {
    position: absolute;
    top: 100%;
    left: 0;
    right: 0;
    background: var(--bg-primary);
    border: 2px solid var(--primary-color);
    border-top: none;
    border-radius: 0 0 var(--radius-lg) var(--radius-lg);
    max-height: 250px;
    overflow-y: auto;
    z-index: 1000;
    display: none;
    box-shadow: var(--shadow-lg);
    -webkit-backdrop-filter: blur(10px);
    backdrop-filter: blur(10px);
}

.medication-option {
    padding: var(--space-md);
    cursor: pointer;
    border-bottom: 1px solid var(--gray-100);
    transition: all var(--transition-fast);
    font-size: 0.875rem;
    position: relative;
}

.medication-option:hover {
    background: linear-gradient(135deg, var(--primary-light) 0%, var(--bg-secondary) 100%);
    color: var(--primary-color);
    transform: translateX(4px);
}

.medication-option:last-child {
    border-bottom: none;
}

.selected-medications {
    margin-top: var(--space-md);
    display: flex;
    flex-wrap: wrap;
    gap: var(--space-sm);
}

.medication-tag {
    display: inline-flex;
    align-items: center;
    background: linear-gradient(135deg, var(--primary-color) 0%, var(--accent-color) 100%);
    color: var(--text-inverse);
    padding: var(--space-sm) var(--space-md);
    border-radius: var(--radius-full);
    font-size: 0.8125rem;
    font-weight: 500;
    cursor: pointer;
    transition: all var(--transition-normal);
    box-shadow: var(--shadow-sm);
    position: relative;
    overflow: hidden;
}

.medication-tag:hover {
    transform: translateY(-2px);
    box-shadow: var(--shadow-md);
    background: linear-gradient(135deg, var(--primary-hover) 0%, var(--accent-color) 100%);
}

.medication-tag .remove {
    margin-left: var(--space-sm);
    font-weight: bold;
    width: 18px;
    height: 18px;
    border-radius: var(--radius-full);
    background: rgba(255, 255, 255, 0.2);
    display: flex;
    align-items: center;
    justify-content: center;
    transition: background var(--transition-fast);
}

.medication-tag .remove:hover {
    background: rgba(255, 255, 255, 0.3);
}

/* Modern Button Styles */
.btn {
    display: inline-flex;
    align-items: center;
    justify-content: center;
    gap: var(--space-sm);
    padding: var(--space-md) var(--space-xl);
    font-size: 1rem;
    font-weight: 600;
    text-align: center;
    text-decoration: none;
    border: none;
    border-radius: var(--radius-lg);
    cursor: pointer;
    transition: all var(--transition-normal);
    position: relative;
    overflow: hidden;
    font-family: var(--font-primary);
    white-space: nowrap;
}

.btn::before {
    content: '';
    position: absolute;
    top: 0;
    left: -100%;
    width: 100%;
    height: 100%;
    background: linear-gradient(90deg, transparent, rgba(255, 255, 255, 0.2), transparent);
    transition: left var(--transition-slow);
}

.btn:hover::before {
    left: 100%;
}

.btn-primary {
    background: linear-gradient(135deg, var(--primary-color) 0%, var(--accent-color) 100%);
    color: var(--text-inverse);
    box-shadow: var(--shadow-md);
}

.btn-primary:hover {
    transform: translateY(-2px);
    box-shadow: var(--shadow-lg);
    background: linear-gradient(135deg, var(--primary-hover) 0%, var(--accent-color) 100%);
}

.btn-primary:active {
    transform: translateY(0);
    box-shadow: var(--shadow-sm);
}

.btn-block {
    width: 100%;
    margin-top: var(--space-xl);
}

/* Enhanced Main Content */
.main-content {
    flex: 1;
    padding: var(--space-xl);
    overflow-y: auto;
    background: var(--bg-primary);
    position: relative;
}

/* Modern Initial Instructions */
.initial-instructions {
    display: flex;
    justify-content: center;
    align-items: center;
    height: 60vh;
    text-align: center;
    animation: fadeIn 0.8s ease-out;
}

.instruction-content {
    max-width: 600px;
    padding: var(--space-2xl);
    background: linear-gradient(135deg, var(--bg-primary) 0%, var(--bg-secondary) 100%);
    border-radius: var(--radius-xl);
    border: 1px solid var(--gray-200);
    box-shadow: var(--shadow-xl);
    position: relative;
    overflow: hidden;
}

.instruction-content::before {
    content: '';
    position: absolute;
    top: 0;
    left: 0;
    right: 0;
    height: 4px;
    background: linear-gradient(to right, var(--primary-color), var(--accent-color));
}

.instruction-content h3 {
    color: var(--text-primary);
    margin-bottom: var(--space-lg);
    font-size: 1.75rem;
    font-weight: 700;
}

.instruction-content p {
    color: var(--text-secondary);
    font-size: 1.125rem;
    line-height: 1.7;
}

/* Enhanced Warning and Error Messages */
.warning-message, .error-message {
    padding: var(--space-lg);
    border-radius: var(--radius-lg);
    margin-bottom: var(--space-lg);
    border-left: 4px solid;
    animation: slideInRight 0.4s ease-out;
    -webkit-backdrop-filter: blur(10px);
    backdrop-filter: blur(10px);
}

.warning-message {
    background: linear-gradient(135deg, rgba(217, 119, 6, 0.1) 0%, rgba(245, 158, 11, 0.05) 100%);
    border-left-color: var(--warning-color);
    color: #92400e;
}

.error-message {
    background: linear-gradient(135deg, rgba(220, 38, 38, 0.1) 0%, rgba(239, 68, 68, 0.05) 100%);
    border-left-color: var(--error-color);
    color: #991b1b;
}

/* Modern Results Container */
.results-container {
    animation: fadeInUp 0.6s ease-out;
    max-width: none;
}

/* Enhanced Medication Recommendations */
.medication-recommendations {
    margin-bottom: var(--space-3xl);
}

.medication-recommendations h2 {
    color: var(--text-primary);
    margin-bottom: var(--space-xl);
    font-size: 2.25rem;
    font-weight: 700;
    display: flex;
    align-items: center;
    gap: var(--space-md);
}

.medication-recommendations h2::before {
    content: '💊';
    font-size: 2rem;
}

.medication-results-container {
    display: grid;
    gap: var(--space-xl);
}

/* Modern Medication Cards */
.medication-card {
    background: var(--bg-primary);
    border: 1px solid var(--gray-200);
    border-radius: var(--radius-xl);
    box-shadow: var(--shadow-lg);
    overflow: hidden;
    transition: all var(--transition-normal);
    position: relative;
}

.medication-card:hover {
    transform: translateY(-4px);
    box-shadow: var(--shadow-xl);
    border-color: var(--primary-color);
}

.medication-header {
    background: linear-gradient(135deg, var(--bg-secondary) 0%, var(--bg-tertiary) 100%);
    padding: var(--space-xl);
    border-bottom: 1px solid var(--gray-200);
    cursor: pointer;
    -webkit-user-select: none;
    user-select: none;
    transition: all var(--transition-normal);
    position: relative;
}

.medication-header::before {
    content: '';
    position: absolute;
    top: 0;
    left: 0;
    right: 0;
    height: 3px;
    background: linear-gradient(to right, var(--primary-color), var(--accent-color));
    opacity: 0;
    transition: opacity var(--transition-normal);
}

.medication-header:hover::before {
    opacity: 1;
}

.medication-header h3 {
    margin: 0;
    color: var(--text-primary);
    font-size: 1.375rem;
    font-weight: 700;
    display: flex;
    justify-content: space-between;
    align-items: center;
}

.expand-icon {
    transition: transform var(--transition-normal);
    font-size: 1.25rem;
    color: var(--text-tertiary);
}

.medication-header.expanded .expand-icon {
    transform: rotate(180deg);
    color: var(--primary-color);
}

.medication-content {
    padding: 0;
    max-height: 0;
    overflow: hidden;
    transition: all var(--transition-slow);
}

.medication-content.expanded {
    padding: var(--space-xl);
    max-height: 1000px;
}

.medication-grid {
    display: grid;
    grid-template-columns: 1fr 1fr;
    gap: var(--space-2xl);
}

.rfe-section, .dosing-section {
    padding: var(--space-xl);
    border-radius: var(--radius-lg);
    position: relative;
    overflow: hidden;
}

.rfe-section {
    background: linear-gradient(135deg, var(--primary-light) 0%, rgba(37, 99, 235, 0.05) 100%);
    border: 1px solid rgba(37, 99, 235, 0.2);
}

.dosing-section {
    background: linear-gradient(135deg, var(--bg-secondary) 0%, var(--bg-tertiary) 100%);
    border: 1px solid var(--gray-200);
}

.rfe-section h4, .dosing-section h4 {
    margin-bottom: var(--space-lg);
    color: var(--text-primary);
    font-size: 1.25rem;
    font-weight: 700;
    display: flex;
    align-items: center;
    gap: var(--space-sm);
}

/* Enhanced Metric Display */
.metric {
    text-align: center;
    border: 1px solid var(--gray-200);
    border-radius: var(--radius-lg);
    padding: var(--space-xl);
    background: linear-gradient(135deg, var(--bg-primary) 0%, var(--bg-secondary) 100%);
    box-shadow: var(--shadow-md);
    transition: all var(--transition-normal);
    position: relative;
    overflow: hidden;
}

.metric::before {
    content: '';
    position: absolute;
    top: 0;
    left: 0;
    right: 0;
    height: 3px;
    background: linear-gradient(to right, var(--primary-color), var(--accent-color));
}

.metric:hover {
    transform: translateY(-2px);
    box-shadow: var(--shadow-lg);
}

.metric-value {
    font-size: 2.5rem;
    font-weight: 800;
    color: var(--primary-color);
    margin-bottom: var(--space-sm);
    font-feature-settings: 'tnum';
    line-height: 1;
}

.metric-label {
    font-size: 0.875rem;
    color: var(--text-tertiary);
    font-weight: 600;
    text-transform: uppercase;
    letter-spacing: 0.05em;
    margin-bottom: var(--space-xs);
}

.metric-help {
    font-size: 0.75rem;
    color: var(--text-tertiary);
    margin-top: var(--space-sm);
    line-height: 1.4;
}

.metric-unit {
    display: block;
    font-size: 0.875rem;
    color: var(--text-secondary);
    margin-top: var(--space-sm);
    font-weight: 500;
}

/* Modern Recommendation Boxes */
.recommendation-box {
    background: linear-gradient(135deg, rgba(37, 99, 235, 0.1) 0%, rgba(6, 182, 212, 0.05) 100%);
    border-left: 4px solid var(--primary-color);
    padding: var(--space-xl);
    border-radius: var(--radius-lg);
    margin-bottom: var(--space-lg);
    position: relative;
    -webkit-backdrop-filter: blur(10px);
    backdrop-filter: blur(10px);
    animation: slideInRight 0.4s ease-out;
}

.recommendation-box::before {
    content: '⚠️';
    position: absolute;
    top: var(--space-lg);
    left: var(--space-lg);
    font-size: 1.25rem;
    opacity: 0.7;
}

.recommendation-box p {
    margin: 0;
    padding-left: var(--space-2xl);
    color: var(--primary-color);
    font-weight: 500;
    line-height: 1.6;
}

.no-adjustment-box {
    background: linear-gradient(135deg, rgba(5, 150, 105, 0.1) 0%, rgba(16, 185, 129, 0.05) 100%);
    border-left: 4px solid var(--success-color);
    padding: var(--space-xl);
    border-radius: var(--radius-lg);
    margin-bottom: var(--space-lg);
    position: relative;
    -webkit-backdrop-filter: blur(10px);
    backdrop-filter: blur(10px);
    animation: slideInRight 0.4s ease-out;
}

.no-adjustment-box::before {
    content: '✅';
    position: absolute;
    top: var(--space-lg);
    left: var(--space-lg);
    font-size: 1.25rem;
}

.no-adjustment-box p {
    margin: 0;
    padding-left: var(--space-2xl);
    color: var(--success-color);
    font-weight: 500;
    line-height: 1.6;
}

.dosing-limit {
    font-size: 0.875rem;
    color: var(--text-secondary);
    margin-top: var(--space-md);
    padding: var(--space-md);
    background: var(--bg-secondary);
    border-radius: var(--radius-md);
    border: 1px solid var(--gray-200);
}

.uptodate-link {
    display: inline-flex;
    align-items: center;
    gap: var(--space-sm);
    margin-top: var(--space-lg);
    padding: var(--space-md) var(--space-lg);
    background: linear-gradient(135deg, var(--accent-color) 0%, var(--primary-color) 100%);
    color: var(--text-inverse);
    text-decoration: none;
    border-radius: var(--radius-lg);
    font-size: 0.875rem;
    font-weight: 600;
    transition: all var(--transition-normal);
    box-shadow: var(--shadow-sm);
}

.uptodate-link:hover {
    transform: translateY(-2px);
    box-shadow: var(--shadow-md);
    text-decoration: none;
    color: var(--text-inverse);
}

.uptodate-link::after {
    content: '↗';
    font-size: 1rem;
}

.warning-note {
    background: linear-gradient(135deg, rgba(217, 119, 6, 0.1) 0%, rgba(245, 158, 11, 0.05) 100%);
    border: 1px solid rgba(217, 119, 6, 0.3);
    color: #92400e;
    padding: var(--space-lg);
    border-radius: var(--radius-lg);
    margin-bottom: var(--space-lg);
    font-size: 0.875rem;
    line-height: 1.5;
    position: relative;
    padding-left: var(--space-2xl);
}

.warning-note::before {
    content: '⚠️';
    position: absolute;
    top: var(--space-lg);
    left: var(--space-lg);
    font-size: 1rem;
}

/* Enhanced Patient Profile Section */
.patient-profile {
    margin-bottom: var(--space-3xl);
}

.patient-profile h2 {
    color: var(--text-primary);
    margin-bottom: var(--space-xl);
    font-size: 2.25rem;
    font-weight: 700;
    display: flex;
    align-items: center;
    gap: var(--space-md);
}

.patient-profile h2::before {
    content: '📊';
    font-size: 2rem;
}

/* Modern Tabs */
.tabs {
    display: flex;
    border-bottom: 2px solid var(--gray-200);
    margin-bottom: var(--space-xl);
    background: var(--bg-secondary);
    border-radius: var(--radius-lg) var(--radius-lg) 0 0;
    overflow: hidden;
}

.tab-button {
    background: none;
    border: none;
    padding: var(--space-lg) var(--space-xl);
    cursor: pointer;
    color: var(--text-secondary);
    font-size: 1rem;
    font-weight: 600;
    border-bottom: 3px solid transparent;
    transition: all var(--transition-normal);
    position: relative;
    flex: 1;
}

.tab-button::before {
    content: '';
    position: absolute;
    top: 0;
    left: 0;
    right: 0;
    bottom: 0;
    background: linear-gradient(135deg, var(--primary-color) 0%, var(--accent-color) 100%);
    opacity: 0;
    transition: opacity var(--transition-normal);
}

.tab-button span {
    position: relative;
    z-index: 1;
}

.tab-button.active {
    color: var(--text-inverse);
    border-bottom-color: var(--primary-color);
}

.tab-button.active::before {
    opacity: 1;
}

.tab-button:hover:not(.active) {
    color: var(--primary-color);
    background: rgba(37, 99, 235, 0.05);
}

.tab-content {
    display: none;
    animation: fadeInUp 0.4s ease-out;
}

.tab-content.active {
    display: block;
}

/* Enhanced Profile Grid */
.profile-grid {
    display: grid;
    grid-template-columns: repeat(auto-fit, minmax(320px, 1fr));
    gap: var(--space-xl);
}

.profile-card {
    background: linear-gradient(135deg, var(--bg-primary) 0%, var(--bg-secondary) 100%);
    border: 1px solid var(--gray-200);
    border-radius: var(--radius-xl);
    padding: var(--space-xl);
    box-shadow: var(--shadow-lg);
    position: relative;
    overflow: hidden;
    transition: all var(--transition-normal);
}

.profile-card::before {
    content: '';
    position: absolute;
    top: 0;
    left: 0;
    right: 0;
    height: 4px;
    background: linear-gradient(to right, var(--primary-color), var(--accent-color));
}

.profile-card:hover {
    transform: translateY(-4px);
    box-shadow: var(--shadow-xl);
}

.profile-header {
    font-size: 1.375rem;
    font-weight: 700;
    margin-bottom: var(--space-lg);
    text-align: center;
    color: var(--text-primary);
}

.info-box {
    background: linear-gradient(135deg, var(--primary-light) 0%, rgba(37, 99, 235, 0.05) 100%);
    border: 1px solid rgba(37, 99, 235, 0.2);
    color: var(--primary-color);
    padding: var(--space-lg);
    border-radius: var(--radius-lg);
    font-size: 0.875rem;
    font-weight: 600;
    margin-top: var(--space-md);
    text-align: center;
}

/* Enhanced Chart Container */
.chart-container {
    background: linear-gradient(135deg, var(--bg-primary) 0%, var(--bg-secondary) 100%);
    border: 1px solid var(--gray-200);
    border-radius: var(--radius-xl);
    padding: var(--space-xl);
    box-shadow: var(--shadow-lg);
    position: relative;
    overflow: hidden;
}

.chart-container::before {
    content: '';
    position: absolute;
    top: 0;
    left: 0;
    right: 0;
    height: 4px;
    background: linear-gradient(to right, var(--primary-color), var(--accent-color));
}

.rfe-section h3 {
    color: var(--text-primary);
    margin-bottom: var(--space-lg);
    font-size: 1.5rem;
    font-weight: 700;
}

#rfeChart {
    border-radius: var(--radius-lg);
}

/* Enhanced Footer */
.footer {
    background: linear-gradient(135deg, var(--gray-900) 0%, var(--gray-800) 100%);
    color: var(--text-inverse);
    text-align: center;
    padding: var(--space-3xl) var(--space-xl);
    margin-top: var(--space-4xl);
    position: relative;
    overflow: hidden;
}

.footer::before {
    content: '';
    position: absolute;
    top: 0;
    left: 0;
    right: 0;
    height: 1px;
    background: linear-gradient(to right, transparent 0%, var(--primary-color) 50%, transparent 100%);
}

.footer p {
    margin: 0;
    font-size: 0.875rem;
    opacity: 0.8;
    line-height: 1.6;
}

.footer strong {
    color: var(--primary-light);
    font-weight: 600;
}

.disclaimer-section {
    margin-bottom: var(--space-lg);
}

.disclaimer-details {
    border: 1px solid rgba(255, 255, 255, 0.1);
    border-radius: var(--radius-lg);
    overflow: hidden;
    background: rgba(255, 255, 255, 0.05);
    -webkit-backdrop-filter: blur(10px);
    backdrop-filter: blur(10px);
}

.disclaimer-summary {
    background: transparent;
    padding: var(--space-lg) var(--space-xl);
    cursor: pointer;
    font-weight: 600;
    color: var(--text-inverse);
    list-style: none;
    -webkit-user-select: none;
    user-select: none;
    transition: all var(--transition-normal);
}

.disclaimer-summary::-webkit-details-marker {
    display: none;
}

.disclaimer-summary::before {
    content: "▶";
    margin-right: var(--space-sm);
    transition: transform var(--transition-normal);
    display: inline-block;
}

.disclaimer-summary:hover {
    background: rgba(255, 255, 255, 0.1);
}

.disclaimer-details[open] .disclaimer-summary::before {
    transform: rotate(90deg);
}

.disclaimer-content {
    padding: var(--space-xl);
    background: rgba(255, 255, 255, 0.05);
    border-top: 1px solid rgba(255, 255, 255, 0.1);
}

.warning-box {
    background: linear-gradient(135deg, rgba(217, 119, 6, 0.15) 0%, rgba(245, 158, 11, 0.1) 100%);
    border: 1px solid rgba(217, 119, 6, 0.3);
    color: #fbbf24;
    padding: var(--space-lg);
    border-radius: var(--radius-lg);
    margin-bottom: var(--space-lg);
}

.footer-credit {
    text-align: center;
    color: rgba(255, 255, 255, 0.7);
    font-size: 0.875rem;
    margin-top: var(--space-lg);
}

/* Enhanced Loading States */
.loading {
    display: flex;
    align-items: center;
    justify-content: center;
    padding: var(--space-3xl);
    color: var(--text-secondary);
    font-size: 1.125rem;
    min-height: 200px;
}

.loading::before {
    content: '';
    width: 2rem;
    height: 2rem;
    border: 3px solid var(--gray-200);
    border-top: 3px solid var(--primary-color);
    border-radius: 50%;
    animation: spin 1s linear infinite;
    margin-right: var(--space-md);
}

.error {
    background: linear-gradient(135deg, rgba(239, 68, 68, 0.1) 0%, rgba(220, 38, 38, 0.05) 100%);
    border: 1px solid rgba(239, 68, 68, 0.3);
    color: #dc2626;
    padding: var(--space-xl);
    border-radius: var(--radius-lg);
    margin: var(--space-lg) 0;
    text-align: center;
    font-weight: 500;
    position: relative;
    padding-left: var(--space-2xl);
}

.error::before {
    content: '❌';
    position: absolute;
    top: var(--space-xl);
    left: var(--space-xl);
    font-size: 1.25rem;
}

/* Enhanced Animations */
@keyframes spin {
    0% { transform: rotate(0deg); }
    100% { transform: rotate(360deg); }
}

@keyframes fadeInUp {
    from {
        opacity: 0;
        transform: translateY(1rem);
    }
    to {
        opacity: 1;
        transform: translateY(0);
    }
}

@keyframes slideInRight {
    from {
        opacity: 0;
        transform: translateX(1rem);
    }
    to {
        opacity: 1;
        transform: translateX(0);
    }
}

@keyframes slideInLeft {
    from {
        opacity: 0;
        transform: translateX(-1rem);
    }
    to {
        opacity: 1;
        transform: translateX(0);
    }
}

@keyframes scaleIn {
    from {
        opacity: 0;
        transform: scale(0.9);
    }
    to {
        opacity: 1;
        transform: scale(1);
    }
}

@keyframes fadeIn {
    from {
        opacity: 0;
    }
    to {
        opacity: 1;
    }
}

@keyframes bounce {
    0%, 20%, 53%, 80%, 100% {
        animation-timing-function: cubic-bezier(0.215, 0.61, 0.355, 1);
        transform: translate3d(0, 0, 0);
    }
    40%, 43% {
        animation-timing-function: cubic-bezier(0.755, 0.05, 0.855, 0.06);
        transform: translate3d(0, -0.5rem, 0);
    }
    70% {
        animation-timing-function: cubic-bezier(0.755, 0.05, 0.855, 0.06);
        transform: translate3d(0, -0.25rem, 0);
    }
    90% {
        transform: translate3d(0, -0.125rem, 0);
    }
}

/* Enhanced Responsive Design */
@media (max-width: 768px) {
    :root {
        --space-xs: 0.25rem;
        --space-sm: 0.5rem;
        --space-md: 0.75rem;
        --space-lg: 1rem;
        --space-xl: 1.25rem;
        --space-2xl: 1.5rem;
        --space-3xl: 2rem;
    }

    body {
        padding: 0;
    }

    .main-container {
        min-height: 100vh;
    }

    .content-wrapper {
        grid-template-columns: 1fr;
        margin-top: 0;
        border-radius: 0;
        box-shadow: none;
        gap: 0;
    }
    
    .sidebar {
        width: 100%;
        order: 1;
        border-right: none;
        border-bottom: 1px solid var(--gray-200);
        background: var(--bg-secondary);
    }
    
    .main-content {
        order: 2;
        padding: var(--space-md);
        min-height: 0;
    }
    
    .sidebar-content {
        padding: var(--space-md);
    }
    
    .header {
        padding: var(--space-md) var(--space-md) var(--space-lg);
        background: linear-gradient(135deg, var(--primary-color) 0%, var(--accent-color) 100%);
        border-radius: 0;
        margin-top: 0;
    }
    
    .header h1 {
        font-size: 1.5rem;
        text-align: center;
        margin-bottom: var(--space-sm);
        line-height: 1.2;
    }

    .header p {
        font-size: 0.875rem;
        text-align: center;
        margin: 0;
        opacity: 0.9;
    }
    
    .form-grid {
        grid-template-columns: 1fr;
        gap: var(--space-md);
    }

    .form-row {
        grid-template-columns: 1fr;
        gap: var(--space-sm);
    }

    .form-group {
        margin-bottom: var(--space-md);
    }

    .form-group label {
        font-size: 0.875rem;
        font-weight: 600;
        margin-bottom: var(--space-xs);
    }

    .form-control {
        padding: var(--space-md);
        font-size: 1rem;
        min-height: 48px;
        border-radius: var(--radius-md);
    }

    .btn {
        width: 100%;
        justify-content: center;
        padding: var(--space-md) var(--space-lg);
        font-size: 1rem;
        min-height: 48px;
        border-radius: var(--radius-md);
    }

    .metrics-grid {
        grid-template-columns: 1fr;
        gap: var(--space-md);
    }

    .medication-grid {
        grid-template-columns: 1fr;
        gap: var(--space-md);
    }
    
    .profile-grid {
        grid-template-columns: 1fr;
        gap: var(--space-md);
    }
    
    .tabs {
        flex-direction: column;
        border-radius: var(--radius-md);
        background: var(--bg-secondary);
        border: 1px solid var(--gray-200);
        overflow: hidden;
    }
    
    .tab-button {
        text-align: left;
        border-bottom: 1px solid var(--gray-200);
        border-right: none;
        padding: var(--space-md);
        border-radius: 0;
        background: transparent;
        position: relative;
    }

    .tab-button:last-child {
        border-bottom: none;
    }
    
    .tab-button.active {
        background: var(--primary-light);
        color: var(--primary-color);
        font-weight: 600;
    }

    .tab-button.active::after {
        content: '';
        position: absolute;
        left: 0;
        top: 0;
        bottom: 0;
        width: 4px;
        background: var(--primary-color);
    }

    .medication-card {
        padding: var(--space-md);
        margin-bottom: var(--space-md);
        border-radius: var(--radius-md);
        box-shadow: var(--shadow-sm);
    }

    .metric-value {
        font-size: 1.75rem;
    }

    .patient-profile h2,
    .medication-recommendations h2 {
        font-size: 1.25rem;
        text-align: center;
        margin-bottom: var(--space-md);
    }

    .instruction-content {
        padding: var(--space-md);
        margin: var(--space-md);
        border-radius: var(--radius-md);
    }

    .recommendation-box,
    .no-adjustment-box,
    .warning-note,
    .error {
        padding: var(--space-md);
        border-radius: var(--radius-md);
        margin-bottom: var(--space-md);
    }

    .medication-select-container {
        margin-bottom: var(--space-md);
    }

    .medication-dropdown {
        max-height: 200px;
        border-radius: var(--radius-md);
    }

    .medication-option {
        padding: var(--space-md);
        border-bottom: 1px solid var(--gray-100);
        font-size: 0.875rem;
    }

    .selected-medications {
        gap: var(--space-xs);
        margin-top: var(--space-sm);
    }

    .selected-medication {
        padding: var(--space-xs) var(--space-sm);
        font-size: 0.75rem;
        border-radius: var(--radius-sm);
    }

    .help-text {
        font-size: 0.75rem;
        margin-top: var(--space-xs);
    }

    .input-section {
        margin-bottom: var(--space-lg);
    }

    .input-header {
        font-size: 1rem;
        margin-bottom: var(--space-md);
        padding-bottom: var(--space-xs);
        border-bottom: 2px solid var(--primary-color);
    }
}

@media (max-width: 480px) {
    .header {
        padding: var(--space-sm) var(--space-sm) var(--space-md);
    }

    .header h1 {
        font-size: 1.25rem;
        line-height: 1.1;
    }

    .header p {
        font-size: 0.8rem;
    }

    .sidebar-content {
        padding: var(--space-sm);
    }

    .main-content {
        padding: var(--space-sm);
    }

    .form-control {
        padding: var(--space-sm) var(--space-md);
        font-size: 1rem;
        min-height: 44px;
    }

    .btn {
        padding: var(--space-sm) var(--space-md);
        min-height: 44px;
        font-size: 0.9rem;
    }

    .metric-value {
        font-size: 1.5rem;
    }

    .patient-profile h2,
    .medication-recommendations h2 {
        font-size: 1.125rem;
    }

    .medication-card {
        padding: var(--space-sm);
        margin-bottom: var(--space-sm);
    }

    .profile-card {
        padding: var(--space-sm);
    }

    .instruction-content {
        padding: var(--space-sm);
        margin: var(--space-sm);
    }

    .instruction-content h3 {
        font-size: 1.25rem;
    }

    .instruction-content p {
        font-size: 0.875rem;
    }

    .recommendation-box,
    .no-adjustment-box,
    .warning-note,
    .error {
        padding: var(--space-sm);
        font-size: 0.875rem;
    }

    .tab-button {
        padding: var(--space-sm) var(--space-md);
        font-size: 0.875rem;
    }

    .medication-option {
        padding: var(--space-sm) var(--space-md);
    }

    .selected-medication {
        padding: var(--space-xs);
        font-size: 0.7rem;
    }

    .help-text {
        font-size: 0.7rem;
    }

    .input-header {
        font-size: 0.9rem;
        margin-bottom: var(--space-sm);
    }

    .form-group {
        margin-bottom: var(--space-sm);
    }

    .form-group label {
        font-size: 0.8rem;
    }
}

/* Enhanced Print Styles */
@media print {
    * {
        box-shadow: none !important;
        text-shadow: none !important;
    }

    body {
        background: white;
        color: black;
        font-size: 12pt;
        line-height: 1.4;
    }

    .header {
        background: white;
        color: black;
        border-bottom: 2px solid black;
        margin-bottom: 1rem;
    }

    .sidebar {
        display: none !important;
    }
    
    .main-content {
        width: 100% !important;
        padding: 0 !important;
    }
    
    .btn {
        display: none !important;
    }
    
    .tab-content {
        display: block !important;
    }
    
    .medication-content {
        display: block !important;
        max-height: none !important;
        padding: 1rem !important;
    }

    .no-print {
        display: none !important;
    }

    .medication-card,
    .profile-card,
    .chart-container {
        break-inside: avoid;
        border: 1px solid black;
        margin-bottom: 1rem;
    }

    .recommendation-box,
    .no-adjustment-box {
        border: 1px solid black;
        background: white;
        color: black;
    }

    .uptodate-link {
        color: black;
        text-decoration: underline;
    }

    .footer {
        background: white;
        color: black;
        border-top: 1px solid black;
    }
}

/* Utility Classes */
.visually-hidden {
    position: absolute !important;
    width: 1px !important;
    height: 1px !important;
    padding: 0 !important;
    margin: -1px !important;
    overflow: hidden !important;
    clip: rect(0, 0, 0, 0) !important;
    white-space: nowrap !important;
    border: 0 !important;
}

/* Initially hidden elements */
#mainContainer {
    display: none;
}

#resultsContainer {
    display: none;
}

#warningMessage {
    display: none;
}

.text-center { text-align: center; }
.text-left { text-align: left; }
.text-right { text-align: right; }

.font-bold { font-weight: 700; }
.font-semibold { font-weight: 600; }
.font-medium { font-weight: 500; }
.font-normal { font-weight: 400; }

.text-primary { color: var(--primary-color); }
.text-secondary { color: var(--text-secondary); }
.text-muted { color: var(--text-tertiary); }
.text-success { color: var(--success-color); }
.text-warning { color: var(--warning-color); }
.text-error { color: var(--error-color); }

.bg-primary { background-color: var(--primary-color); }
.bg-secondary { background-color: var(--bg-secondary); }
.bg-success { background-color: var(--success-color); }
.bg-warning { background-color: var(--warning-color); }
.bg-error { background-color: var(--error-color); }

.rounded { border-radius: var(--radius-md); }
.rounded-lg { border-radius: var(--radius-lg); }
.rounded-xl { border-radius: var(--radius-xl); }

.shadow { box-shadow: var(--shadow-sm); }
.shadow-md { box-shadow: var(--shadow-md); }
.shadow-lg { box-shadow: var(--shadow-lg); }
.shadow-xl { box-shadow: var(--shadow-xl); }

.m-0 { margin: 0; }
.mt-auto { margin-top: auto; }
.mb-auto { margin-bottom: auto; }

.hidden { display: none; }
.block { display: block; }
.inline-block { display: inline-block; }
.flex { display: flex; }
.inline-flex { display: inline-flex; }
.grid { display: grid; }

.items-center { align-items: center; }
.justify-center { justify-content: center; }
.justify-between { justify-content: space-between; }

.w-full { width: 100%; }
.h-full { height: 100%; }

/* Mobile-specific enhancements */
@media (max-width: 768px) {
    /* Improve touch targets */
    .medication-option:hover,
    .medication-option:focus {
        background: var(--primary-light);
        color: var(--primary-color);
    }

    /* Better scrolling for sidebar */
    .sidebar {
        position: relative;
    }

    /* Sticky calculate button on mobile */
    .btn-primary {
        position: sticky;
        bottom: var(--space-md);
        z-index: 10;
        box-shadow: var(--shadow-lg);
    }

    /* Improved spacing for mobile forms */
    .sidebar-content > h2 {
        margin-bottom: var(--space-md);
        font-size: 1.25rem;
        text-align: center;
        color: var(--primary-color);
    }

    /* Better mobile chart display */
    .chart-container {
        padding: var(--space-sm);
        margin: var(--space-sm) 0;
    }

    /* Improved mobile tabs */
    .tab-content {
        padding: var(--space-md);
    }

    /* Mobile-friendly warnings and alerts */
    .warning-message {
        border-radius: var(--radius-md);
        padding: var(--space-md);
        margin: var(--space-md) 0;
        font-size: 0.875rem;
    }

    /* Better mobile typography */
    .medication-header h3 {
        font-size: 1.125rem;
        line-height: 1.3;
    }

    /* Improved mobile dropdown */
    .medication-dropdown {
        position: absolute;
        z-index: 1000;
        width: 100%;
        box-shadow: var(--shadow-lg);
        border: 1px solid var(--gray-300);
    }

    /* Better mobile grid spacing */
    .metrics-grid .metric {
        padding: var(--space-md);
        text-align: center;
    }

    /* Mobile-friendly footer */
    .footer {
        padding: var(--space-md);
        text-align: center;
    }

    .disclaimer-details {
        margin: var(--space-md) 0;
    }

    .disclaimer-summary {
        padding: var(--space-md);
        font-size: 0.875rem;
        text-align: center;
    }

    .disclaimer-content {
        padding: var(--space-md);
        font-size: 0.8rem;
        line-height: 1.4;
    }
}

/* Additional mobile optimizations for very small screens */
@media (max-width: 360px) {
    .header h1 {
        font-size: 1.125rem;
    }

    .form-control,
    .btn {
        min-height: 40px;
        font-size: 0.875rem;
    }

    .sidebar-content {
        padding: var(--space-xs);
    }

    .main-content {
        padding: var(--space-xs);
    }

    .medication-card,
    .profile-card {
        padding: var(--space-xs);
    }

    .instruction-content {
        padding: var(--space-xs);
        margin: var(--space-xs);
    }
}